|
nM
|
nM
|
mg/kg
|
SC-53228 |
K
D = 1.3 | IC50 = 32 (chemotaxis) | ED50 = 0.07 (dermal PMN migration, guinea pig) |
Tsai et al., 1994
|
| | IC50 = 19 (degranulation) | |
Fretland et al., 1995 |
ONO-4057 |
K
i = 3.7 | IC50 = 300 (homotypic aggregation) | ED50 = 5.3 (dermal PMN migration, guinea pig) |
Kishikawa et al., 1992
|
| | IC50 = 700 (calcium mobilization) | ED50 = 25.6 (neutropenia, guinea pig) |
| | IC50 = 900 (chemotaxis) |
| | IC50 = 1600 (degranulation) |
SB-201993 |
K
i = 7.1 | IC50 = 131 (calcium mobilization) | ED50 = 7.1 (PMN peritonitis, mouse) |
Daines et al., 1993
|
| | IC50 = 268 (degranulation) |
SB-209247 |
K
i = 0.88 | IC50 = 117 (degranulation) | ED50 = 18.7 (arachidonic-induced edema, mouse) |
Sarau et al., 1995
|
| | IC50 = 6.6 (calcium mobilization) | ED50 = 14.8 (arachidonic-induced PMN migration, mouse) |
CP 105,606 | IC50 = 8.0 | IC50 = 5.0 (chemotaxis) | ED50 = 4.2 (dermal PMN migration, mouse) |
Koch et al., 1994
|
| | pA2 = 8.2 (CD11b upregulation) | ED50 = 0.3 (dermal PMN migration, guinea pig) |
Showell et al., 1995 |
CGS-25019C | IC50 = 4 | IC50 = 2.4 (chemotaxis) | ED50 = 3 (neutropenia at 4 h, rat) |
Fujimoto et al., 1994
|
| | IC50 = 0.1 (homotypic aggregation) | ED50 = 11 (neutropenia at 18 h, rat) |
Marshall, 1994 |
| | IC50 = 0.3 (CD11b upregulation) | |
Raychaudhuri et al., 1995
|
| | IC50 = 2.0 (calcium mobilization) |
LY293111 |
K
i = 17.6 | IC50 = 6.3 (chemotaxis) | ED50 = 0.4 (airway obstruction, guinea pig) | Current study; S. M. |
| | IC50 = 0.5 (oxidant production by adherent cells) | ED50 ∼ 0.2 (bronchoalveolar chemotaxis, guinea pig) | Silbaugh and P. W. Stengel, unpublished |
| | IC50 = 20 (oxidant production by suspended cells) | | observations |
| | IC50 = 32 (homotypic aggregation) |