Parameter | Unit | CAP | CAP-LZM |
---|---|---|---|
AUC | min · % · ml−1 | 8.3 | 39.6 |
t½β | min−1 | 89.6 | 52.8 |
Clini | ml · min−1 | 3.58 | 0.74 |
Vdss (central) | ml | 308.1 | 43.4 |
Vdss (peripheral) | ml | 503.4 | 62.5 |
The area under the curve (AUC) was calculated up to the last data point with the trapezoidal rule.
t½β; terminal half-life; Clini, initial plasma clearance; Vdss (central) andVdss (peripheral), volumes of distribution at steady state of the central and peripheral compartment, respectively.