Table 4

Effects of PBZ (300 nM) treatment in the presence of 10, 30, and 100 nM prazosin on residual receptors (q) and K_A(μM) on responses to PE in the DVS

	EC₅₀ Control	EC₅₀Treated	E_max Control versus PBZ Treated	K_A	q	n
	μM	μM		μM
Vehicle	1.98 ± 0.6	0.81 ± 0.14^4-a	131.5 ± 7.1 versus 132.5 ± 6.3^4-a			10
PBZ 300 nM	1.58 ± 0.19	51.35 ± 31.94^4-a	130.8 ± 3.7 versus 50.3 ± 15.5^4-150	51.93 ± 15.22^4-a	0.039 ± 0.02	4
+10 nM prazosin protection	1.99 ± 0.11	33.04 ± 7.84^4-a ^4-150	144.3 ± 5.4 versus 115.4 ± 8.4^4-150	311.53 ± 183.79^4-a	0.127 ± 0.03	11
2-h washout of 10 nM prazosin control	1.72 ± 0.57	8.37 ± 2.94^4-a				5
+30 nM prazosin protection	8.56 ± 2.09	32.68 ± 18.79^4-a	130.1 ± 6.1 versus 97.9 ± 7.1^4-150	237.18 ± 196.60^4-a	0.343 ± 0.13	4
2-h washout of 30 nM prazosin control	3.45	3.52				2

E_max values are expressed as a percentage of 100 mM K⁺ contraction. Values are mean ± S.E.M. (n).

Statistical comparisoms: as in Table 3.
One-way analysis of variance was used to compare K_Avalues; none were significantly different (p > .05), but q values were significantly different (p < .05) with q from 10 nM prazosin significantly different than q from 30 nM prazosin protection.
↵4-150 Significantly different from corresponding controls (p < .05).
↵4-a Not significantly different from corresponding controls (p > .05).