Time course of percent protection in rats against MES-induced seizures following single oral doses of compounds administered at approximately three times the ED50 value
| Time of Test (h Postdose) | [S]-AR-R 15896AR (12 mg/kg) | [R]-AR-R 15895AR (60 mg/kg) | [R,S]-AR-R 15035AR (30 mg/kg) |
|---|---|---|---|
| 2 | 100 | 60 | 80 |
| 4 | 70 | 60 | 100 |
| 8 | 30 | 30 | 30 |
| 24 | 0 | 0 | 0 |
n = 10 animals per dose.