Time course of percent protection in mice against MES-induced seizures following single oral doses of the approximate ED98 value for the three compounds
| Time of Test (h Postdose) | [S]-AR-R 15896AR (45 mg/kg) | [R]-AR-R 15895AR (115 mg/kg) | [R,S]-AR-R 15035AR (50 mg/kg) |
|---|---|---|---|
| 0.5 | 100 | 100 | 100 |
| 1.5 | 100 | 90 | 90 |
| 2.0 | 70 | 80 | 40 |
| 4.0 | 30 | 50 | 20 |
| 6.0 | 20 | 20 | 40 |
n = 10 animals per dose.