Antiseizure profiles (ED50 values) in rats of [S]-AR-R 15896AR, [R]-AR-R 15895AR, and [R,S]-AR-R 15035AR following various routes of administration
| Model | [S]-AR-R 15896AR | [R]-AR-R 15895AR2-150 | [R,S]-AR-R 15035AR |
|---|---|---|---|
| MES, i.p. | 4.0 [3–5] | Not done | 5 [4–7] |
| MES, p.o. | 3.7 [3–6] | 20.2 [10–35] | 9.9 [4–17] |
| MES, i.v. | 2.6 [0.6–4.8] | 6.0 [4–8] | 2.7 [1.5–4] |
| MES, s.c. | 2.5 [1.6–3.5] | 15.0 [13–17] | 5.9 [4–8] |
ED50 values are in mg/kg; values in brackets are 95% confidence limits.
↵2-150 Values for AR-15895AR are significantly different from AR-R 15896AR and AR-R 15035AR (Student’s two-tailed t test). Animals received MES at 60 min after i.p., p.o., and s.c. dosing and 15 min after i.v. administration of compounds.