APPENDIX 2

Pentoxifylline mg · kg⁻¹ · h⁻¹	Mean Change from Baseline (−168 h) in TNF Level (pg/ml) Hours after Clot Implantation
Pentoxifylline mg · kg⁻¹ · h⁻¹	1	2	3	6	9	15	24	48	96	240	692
0^4-b	1.93 _÷ ^× 1.14	4.62 _÷ ^× 1.16	2.44 _÷ ^× 1.14	1.20 _÷ ^× 1.17	0.88 _÷ ^× 1.16	0.89 _÷ ^× 1.16	0.81 _÷ ^× 1.26	1.32 _÷ ^× 1.73	1.79 _÷ ^× 1.52	0.54 _÷ ^× 1.30	1.97 _÷ ^× 1.30
0.5^4-c	1.57 _÷ ^× 1.19	8.93 _÷ ^× 145	6.55 _÷ ^× 1.62	1.32 _÷ ^× 1.45	0.79 _÷ ^× 1.46	0.73 _÷ ^× 1.35	0.98 _÷ ^× 1.92	1.70 _÷ ^× 2.01	0.44 _÷ ^× 1.58	0.58 _÷ ^× 1.71	0.32 _÷ ^× 2.50
1.0^4-c	1.99 _÷ ^× 1.28	5.92 _÷ ^× 1.27	2.48 _÷ ^× 1.32	1.00 _÷ ^× 1.00	1.01 _÷ ^× 1.01	1.17 _÷ ^× 1.17	1.85 _÷ ^× 1.14	1.22 _÷ ^× 1.22	1.19 _÷ ^× 1.17	2.03 _÷ ^× 2.03
5.0^4-c	1.68 _÷ ^× 1.40	5.10 _÷ ^× 1.26	1.80 _÷ ^× 1.38	1.00 _÷ ^× 1.00	1.00 _÷ ^× 1.00	1.00 _÷ ^× 1.00	1.00 _÷ ^× 1.00
10^4-c	1.45 _÷ ^× 1.14	5.31 _÷ ^× 1.00	2.16 _÷ ^× 1.00	1.01 _÷ ^× 1.01	1.00 _÷ ^× 1.00	1.00 _÷ ^× 1.00
20^4-c	2.59 _÷ ^× 1.25	7.39 _÷ ^× 1.35	1.46 _÷ ^× 1.00	1.01 _÷ ^× 1.01

Serial geometric mean changes in TNF levels^4-a

↵4-a A 1 S.D. range for mean can be obtained by multiplying and dividing mean by number below it.
↵4-b Mean value averaged over all time points 2.44_÷^× 1.07.
↵4-c Mean value averaged over all time points and doses of pentoxifylline 3.06 _÷^× 1.07.