Table 2

Kinetic and inhibition parameters (SULPH) for DSG 3α-hydroxylation and TOL 4-hydroxylation by CYP2C9 cell line microsomes

3α-OHDSG4-OHTOL
K m(μM)6.588.7
Vmax (pmol · mg−1 · min−1) 1269247
IC50(μM)0.670.21
K i(μM)0.91nd2-a
  • 2-a nd, Not determined.