Effect of R and S-ketoprofen on serum TNF levels in LPS-treated guinea pigs
| Treatment | Serum TNF |
|---|---|
| ng/ml | |
| LPS + vehicle | 16.6 ± 0.61-a |
| LPS + (R)-ketoprofen | 20.2 ± 2.0 |
| LPS + (S)-ketoprofen | 31.0 ± 3.71-b |
| LPS + (R/S)-ketoprofen | 23.5 ± 0.7 |
Guinea pigs were pretreated with 390 μmol/kg (R)-ketoprofen, (S)-ketoprofen or ketoprofen racemate (R/S-ketoprofen) s.c. 30 min before i.p. inoculum of LPS (40 μg/animal). TNF concentration was determined in the serum collected 90 min after LPS treatment. No detectable levels of TNF were found in saline-treated animals.
↵1-a Data are mean ± S.E.M. (4 animals/group) within one experiment, representative of three performed.
↵1-b P < .01 vs. LPS alone by Tukey’s test.