Antagonistic potency of OPC-41061 and OPC-31260 for human and rat AVP receptors
| Ki (nM) | |||||
|---|---|---|---|---|---|
| Human | Rat | ||||
| V2 | V1a | V1b | V2 | V1a | |
| AVP | 0.78 ± 0.08 | 0.84 ± 0.08 | 0.59 ± 0.05 | 0.95 ± 0.31 | 1.45 ± 0.26 |
| OPC-41061 | 0.43 ± 0.06 | 12.3 ± 0.8 | >100,000 | 1.33 ± 0.30 | 325 ± 41 |
| OPC-31260 | 9.42 ± 0.90 | 150 ± 15 | >100,000 | 6.36 ± 1.56 | 524 ± 119 |
Values are expressed as the mean ± S.E.M. of at least four separate determinations performed in duplicate.