The effect of NRM injection of either (A and C) EPIB or (B and C) A-85380 on paw withdrawal latency (±S.E.M.) in the rat hot box 5 min after coadministration of (A and B) CHLOR (0.23 nmol) or (C) MEC (0.8 nmol)
| NRM injection | Latency |
|---|---|
| sec | |
| A | |
| PBS | 8.4 ± 0.3 |
| CHLOR | 10.2 ± 1.3 |
| EPIB | 13.22-a ± 0.9 |
| CHLOR/EPIB | 9.1 ± 0.6 |
| B | |
| PBS | 8.3 ± 0.6 |
| CHLOR | 8.5 ± 0.4 |
| A-85380 | 12.52-a ± 1.0 |
| CHLOR/A-85380 | 9.4 ± 0.8 |
| C | |
| PBS | 8.9 ± 0.69 |
| MEC | 8.2 ± 0.81 |
| EPIB | 14.72-a ± 1.17 |
| MEC/EPIB | 9.1 ± 0.56 |
| A-85380 | 14.72-a ± 1.23 |
| MEC/85380 | 8.2 ± 0.36 |
The same controls were used in (C) for both A-85380 and EPIB.
↵2-a P < .05 difference from PBS control, n= 7–8/group.