Table 2

Effect of chronic canrenoate treatment on plasma levels of aldosterone, bilirubin, alanine aminotransferase (ALAT), sodium and potassium 5 weeks after common bile duct ligation (CBL) or sham-CBL (sham)

P-aldosteroneP-bilirubinP-ALATP-sodiumP-potassium
nM μM U/liter mM
Sham (n = 7)2.15  ± 0.29 2-b 33.1  ± 2.6152.3  ± 2.05.40  ± 0.20
Sham-CAN (n = 8)2.88  ± 1.20 2-b 30.6  ± 1.6148.8  ± 1.55.10  ± 0.11
CBL (n = 8)3.09  ± 1.74127  ± 564.2  ± 6.02-a 146.3  ± 3.95.51  ± 0.15
CBL-CAN (n = 8)2.29  ± 0.77102  ± 1750.0  ± 6.82-a 150.0  ± 2.15.38  ± 0.12
  • Values are mean ± S.E.M.

  • 2-a P < .05 vs. sham-CBL.

  • 2-b Value below detection limit (8.55 μM).