Table 2

Mean pharmacokinetic parameters of etoposide alone, etoposide (with tamoxifen) and etoposide (with cyclosporine)

ParameterEtoposideET + TAMET + CSA
CLs(ml/min/kg)29.3  (13.0)22.6  (5.3)16.02-a  (1.9)
CLnr(ml/min/kg)23.5  (10.5)18.1  (3.6)12.02-a  (1.6)
Clr (ml/min/kg)5.7  (2.5)4.6  (1.7)4.0  (0.7)
Vss(ml/kg)2877 (1586)1764 (739)1217 (424)
  • Mean (±S.D.), n = 5 per group.

  • 2-a P < .05 (one-way ANOVA, Fisher).