Inhibition constants for organic cations to compete with the [14C]tetraethylammonium accumulation by MDCK-OCT1 and MDCK-OCT2 cells
| Compounds | Ki Values for Tetraethylammonium Accumulation | |
|---|---|---|
| OCT1 (μM) | OCT2 (μM) | |
| 1-Methyl-4-phenylpyridinium | 0.8 | 1.8 |
| Cimetidine | 5.7 | 9.4 |
| Quinidine | 14.6 | 19.1 |
| Tetraethylammonium | 46.6 | 52.2 |
| Nicotine | 64.3 | 50.5 |
| N1-Methylnicotinamide | 669.2 | 403.4 |
| Guanidine | 724.2 | 713.6 |