Effect of GHB on THDOC and alphaxalone-mediated increase in [35S]TBPS binding in thalamic ventrobasal nucleus
| Drugs | Specific [35S]TBPS Binding (pmol/mg of Tissue) in Ventrobasal Nucleus |
|---|---|
| Control | 25.6 ± 1.4 |
| THDOC (1 μM) | 36.8 ± 1.8 |
| + GHB (200 μM) | 37.5 ± 2.1 |
| Alphaxalone (1 μM) | 35.6 ± 1.4 |
| + GHB (200 μM) | 36.3 ± 1.9 |
GHB (200 μM), included in vitro along with either THDOC or alphaxalone (1 μM) in the incubation medium, did not significantly alter the specific [35S]TBPS binding in thalamic ventrobasal nucleus. Values are mean ± S.E.M. from four rats.