Comparison of kinetic constants for tirilazad reduction in human liver microsomes
| Liver | Vmax-1 | KM-1 | V/K−1 | Vmax-2 | KM-2 | V/K−2 |
|---|---|---|---|---|---|---|
| HL17 | 13.87 ± 0.71 | 14.24 ± 2.80 | 0.97 | 2.31 ± 0.68 | 0.50 ± 0.24 | 4.62 |
| HL14 | 19.83 ± 1.26 | 19.00 ± 3.98 | 1.04 | 1.43 ± 0.73 | 0.56 ± 0.43 | 2.51 |
Km given in [μM]. Vmaxgiven in pmol/mg of protein/min.