Angiotensin and bradykinin peptide levels in plasma, blood, kidney, heart, aorta and lung of vehicle-treated rats
| Tissue | Ang II (fmol/g) | Ang I (fmol/g) | Ang II/Ang I Ratio (fmol/fmol) | BK-(1–7) (fmol/g) | BK-(1–9) (fmol/g) | BK-(1–7)/BK-(1–9) Ratio (fmol/fmol) |
|---|---|---|---|---|---|---|
| Plasma | 68 ± 8 | 17 ± 2 | 4.3 ± 0.3 | ND | ND | ND |
| Blood | ND | ND | ND | 4.1 ± 0.8 | 2.3 ± 0.5 | 2.1 ± 0.2 |
| Kidney | 221 ± 31 | 53 ± 7 | 4.4 ± 0.4 | 49 ± 7 | 91 ± 19 | 0.60 ± 0.04 |
| Heart | 12 ± 2 | 1.9 ± 0.4 | 9.6 ± 1.6 | 22 ± 2 | 22 ± 3 | 1.2 ± 0.1 |
| Aorta | 50 ± 10 | <20 | ND | 15 ± 3 | 18 ± 6 | 2.4 ± 1.0 |
| Lung | 138 ± 18 | 8 ± 2 | 31 ± 6 | 51 ± 13 | 75 ± 14 | 0.9 ± 0.3 |
Mean ± S.E., n = 16–23, except for aortic BK-(1–7) and BK-(1–9) levels and BK-(1–7)/BK-(1–9) ratio, where values are from experiment 2, n = 8; for experiment 1, aortic BK-(1–7) and BK-(1–9) levels were less than the minimum detectable (<12 fmol/g for each peptide). ND, Not determined.