Brain Region | EC50 (μM) | Emax (U) |
---|---|---|
a. Olfactory bulb | 1.40 ± 4.50j | 0.34 ± 0.06b–e,g,h,k |
b. Hippocampus | 8.15 ± 4.20j | 0.75 ± 0.13a,c–e,g,i,j |
c. Striatum | 1.48 ± 0.53j | 1.41 ± 0.10a,b,d,f,h–k |
d. Cortex | 8.09 ± 4.30j | 1.09 ± 0.12a,b,c,f,h–k |
e. Thalamus | 5.60 ± 1.97j | 1.27 ± 0.05a,b,f,h–k |
f. Midbrain | 2.88 ± 1.16j | 0.54 ± 0.02c–e,g |
g. Superior. colliculi | 5.60 ± 2.40j | 1.23 ± 0.13a,b,f,h–k |
h. Inferior. colliculi | 2.19 ± 0.69j | 0.74 ± 0.03a,c–e,g,i,j |
i. Hypothalamus | 1.91 ± 1.45j | 0.33 ± 0.03b–e,g,h,k |
j. Cerebellum | 19.99 ± 8.60a–i,k | 0.43 ± 0.06b–e,g,h |
k. Hindbrain | 3.12 ± 0.69j | 0.67 ± 0.03a,c–e,g,i |
Whole brain | 1.63 ± 0.50 | 0.83 ± 0.05 |
EC50 and Emax values were calculated using the Michaelis-Menten equation and are presented as mean ±s.e.m. Each brain region was assigned a lowercase letter. These letters, when placed above a value, indicate that the EC50 or Emax values of the relevant brain regions are significantly different from the listed region as determined using a Tukey b test (P < .05).