Table 5

Effects of YM158, pranlukast, montelukast and zafirlukast on LTD4-induced guinea pig ilea contraction

Compound
YM158PranlukastMontelukastZafirlukast
IC50(nM)0.580.120.0790.075
(95% CL)(0.38–0.78)(0.068–0.16) (0.045–0.13) (0.043–0.12) 
  • Values are represented as the mean with 95% CL of 3 to 5 experiments. The mean tension of ileal contraction was 14.00 ± 1.08 g at 1 × 10−9 M LTD4.