Table 4

EC50 values of contractile responses of guinea pig tracheae to various agonists in the presence or absence of YM158

AgonistEC50(nM)P Value
ControlYM158 (1 × 10−6 M)
LTC4 3.93  ± 0.953.74  ± 0.59N.S.
Carbachol206  ± 20210  ± 7.3N.S.
Histamine9570  ± 8817990  ± 451N.S.
  • Values are the mean ± S.E.M. of four experiments. P values are calculated by Student’s t test using SAS. N.S. means no significant difference in EC50 values between control and YM158-treated groups. The maximum tensions of the corresponding control were 3.46 ± 0.11 g at 1 × 10−7 M LTC4, 4.05 ± 0.24 g at 1 × 10−5 M carbachol and 4.23 ± 0.15 g at 3 × 10−4 M histamine.