Table 3

PK-PD parameters for DPDPE in mice3-a

Parameter3-bEstimateSupporting Data
ObservationsStrainDose (mg/kg)
VC(ml/kg)1700  ± 244Blood DPDPE mdr1a(−/−)/FVB10
k10 (min−1)0.121  ± 0.031Blood DPDPE mdr1a(−/−)/FVB10
k12(min−1)0.133  ± 0.014Blood DPDPE mdr1a(−/−)/FVB10
k21(min−1)0.0322  ± 0.0100Blood DPDPE mdr1a(−/−)/FVB10
k13(min−1)0.00681  ± 0.00116Blood/brain DPDPE mdr1a(−/−) 10
k31(min−1)0.0175  ± 0.010Blood/brain DPDPE mdr1a(−/−) 10
EC50(ng/g)12.3  ± 0.2Effect; brain DPDPE mdr1a(−/−) 0.4 – 10
γ7.44  ± 0.63Effect; brain DPDPE mdr1a(−/−) 0.4 – 10
k31a (min−1)0.0324  ± 0.0005Effect; blood/brain DPDPEFVB10
k34(min−1)0.103  ± 0.001Effect; blood/brain DPDPEFVB10
k43 (min−1)0.689  ± 0.012Effect; blood/brain DPDPEFVB10
k45(min−1)0.0675  ± 0.0006Effect; blood/brain DPDPEFVB10
k54 (min−1)0.0275  ± 0.0003Effect; blood/brain DPDPEFVB10

  • ↵3-a Data presented as parameter estimate ± S.D. from nonlinear regression analysis.

  • ↵3-b Refer to figure 1 for parameter designations.