Table 3

Effects of YM158 and seratrodast on U46619- or PGD2-induced contraction of guinea pig tracheae

Compound Conc (M)npKBSchild Plot Analysis
pA2 (95% CL)Slope (95% CL)
YM158
PGD2 1  × 10−8 47.73  ± 0.037.781.48
3  × 10−8 47.81  ± 0.05(7.68–7.91)(1.15–1.81)
1  × 10−7 48.21  ± 0.17
U466193  × 10−9 78.81  ± 0.108.811.02
1  × 10−8 78.85  ± 0.08(8.63–9.09)(0.77–1.28)
3  × 10−8 78.83  ± 0.08
Seratrodast
1  × 10−8 48.53  ± 0.078.421.12
3  × 10−8 48.42  ± 0.12(8.11–9.10)(0.67–1.57)
1  × 10−7 58.64  ± 0.19
  • pKB values are expressed as the mean ± S.E.M. or the mean with 95% CL of the indicated number of experiments.

  • n: The number of experiments.

  • pA2 values and slopes are derived from linear least-squares regression analysis with 95% CL.