Table 2

Effects of YM158, pranlukast, zafirlukast and montelukast on LTD4-induced contraction of guinea pig tracheae

CompoundConcentration (M)npKBSchild Plot Analysis
pA2 (95% CL)Slope (95% CL)
YM1583  × 10−9 78.81  ± 0.088.870.87
1  × 10−8 88.78  ± 0.09(8.65–9.24)(0.62–1.12)
3  × 10−8 78.67  ± 0.08
Pranlukast3  × 10−10 310.19  ± 0.14
1  × 10−9 89.88  ± 0.06
Zafirlukast3  × 10−10 310.09  ± 0.10
Montelukast3  × 10−9 59.14  ± 0.179.680.57
1  × 10−8 49.04  ± 0.13 (8.86–35.04)(0.033–1.10) 
3  × 10−8 38.68  ± 0.21
  • pKB values are expressed as the mean ± S.E.M. or the mean with 95% CL of the indicated number of experiments.

  • n: The number of experiments.

  • —: Not done.

  • pA2 values and slopes are derived from linear least-squares regression analysis with 95% CL.