Duration of action of Sch 50971 on potentiation of pentobarbital-induced loss of righting reflex in guinea pigs
| Compound2-a | Oral dose | Potentiation of loss of righting reflex2-b | ||
|---|---|---|---|---|
| 0.5 hr Pretreatment | 2 hr Pretreatment | 4 hr Pretreatment | ||
| mg/kg | min | |||
| Sch 50971 | 10 | +43 ± 112-c | +44 ± 102-c | +13 ± 12 |
| (R)-α-Methylhistamine | 30 | +42 ± 62-c | — | +6 ± 14 |
| Diphenhydramine | 30 | +52 ± 92-c | +77 ± 212-c | +32 ± 122-c |
| Triazolam | 1 | +89 ± 242-c | +88 ± 142-c | +59 ± 72-c |
| Diazepam | 3 | +64 ± 192-c | — | +18 ± 10 |
↵2-a Drugs or vehicle were given p.o. 30 min, 2 hr or 4 hr before pentobarbital administration (18 mg/kg i.p.).
↵2-b Potentiation of loss of righting reflex is the increase in time when the animal is unable to right itself beyond the recovery of the righting reflex for the respective control groups (i.e., animals receiving saline p.o.). Values are mean ± S.E.M. (n = 5–6 per group).
↵2-c Significantly different from vehicle group at respective pretreatment time (P < .05).