Table 1
In vitro inhibition of several folate requiring enzymes by LY354899
Enzyme
K
i
Dehydrogenase
19 ± 5 nM
Synthetase
>1 μM
rhTS
>100 μM
mGARFT
181 ± 21 μM
rhDHFR
1.35 ± 0.008 μM