Dose | Total cytochrome P450 | Erythromycin demethylation | Delavirdine desalkylation | Residual delavirdine | Residual desalkyl delavirdine |
---|---|---|---|---|---|
mg/kg/day | nmol/mg protein | nmol/min/mg | nmol/mg protein | ||
0 | 1.12 ± 0.05 | 1.18 ± 0.07 | 1.69 ± 0.30 | — | — |
100 | 1.12 ± 0.12 | 0.347 ± 0.0951-a | 0.110 ± 0.0601-a | 1.08 ± 0.24 | 0.064 ± 0.023 |
250 | 0.904 ± 0.188 | 0.293 ± 0.0421-a | 0.071 ± 0.0281-a | 4.96 ± 1.22 | 0.075 ± 0.016 |
Rats were treated daily with the divided doses for 4 weeks followed by preparation and assay of liver microsomes. Values shown are mean ± S.D. of three subjects.
↵1-a Significantly different from control (0 mg/kg/day) at 5% level.