K02 pharmacokinetic parameters calculated using noncompartmental methods
| Study | AUC (mg · min/liter) | CL (ml/min/kg) | CL/F (ml/min/kg) | F (%) | Vss (l/kg) | MRT (min) | MAT (min) | Tmax(min) |
|---|---|---|---|---|---|---|---|---|
| Control | ||||||||
| i.v., 10 mg/kg | 93.8 ± 17.1 | 110 ± 22 | 1.9 ± 0.3 | 17.4 ± 2.0 | ||||
| p.o., 30 mg/kg | 9.4 ± 4.4 | 3810 ± 1620 | 2.9 ± 1.4 | 64.9 ± 14.1 | 40.0 ± 18.0 | |||
| Ketoconazole1-a | ||||||||
| i.v., 10 mg/kg | 107 ± 14 | 95 ± 13 | 2.0 ± 0.6 | 21.4 ± 8.3 | ||||
| p.o., 30 mg/kg | 102 ± 24 | 306 ± 601-b | 31.0 ± 7.51-b | 77.1 ± 39.5 | 46.8 ± 11.7 |