Figure 11

Comparison of effects of T529 mutations on the blocking potency of quinidine and 4AP. The voltage clamp protocols and methods of Kd estimation were as described in figures 7 to 10. The Kd values of quinidine (left ordinate) and those of 4AP (right ordinate) are plotted on a logarithmic scale against channel types along the abscissa (WT = rKv1.4Δ3–25). The following are the Kd values (n = number of measurements):