Table 1

Changes in free water clearance produced by the administration of BW373U86 or SNC80 in conscious rats

PeriodCH20
BW (50 μg/kg/min)BW (30 μg/kg/min)SNC80 (5 mg/kg)
C−31.6  ± 8.3−29.7  ± 4.9−19.1  ± 2.3
B1/S1−14.4  ± 1.1−7.3  ± 4.51-a −11.9  ± 3.7
B2/S2−9.0  ± 3.3−12.5  ± 3.3−3.1  ± 7.1
B3/S3−15.3  ± 4.8−17.9  ± 1.7−3.7  ± 4.0
B4/S4−14.9  ± 3.1−32.6  ± 8.9−13.2  ± 3.7
B5/S5−27.6  ± 9.5−16.7  ± 2.4−13.2  ± 3.9
B6/S6−28.1  ± 4.3−13.8  ± 7.1−18.1  ± 2.4

  • Changes in free water clearance (CH20) produced by the administration of the delta opioid agonist BW373U86 (50 μg/kg/min, n = 5; 30 μg/kg/min i.v.,n = 7), or SNC80 (5 mg/kg, i.v. bolus,n = 5). The values presented are calculated from renal excretory data obtained from the same groups of rats depicted in figures 1 and 3, respectively. Urine samples were collected during control (C, 20 min), and after the administration of either BW (B1 to B6, six consecutive 10 min urine samples beginning 5 min after the start of infusion) or SNC80 (S1 to S6, six consecutive 10 min urine samples beginning immediately after i.v. injection). The values are mean ± S.E.

  • ↵1-a P < .05, significantly different from corresponding control.

  • Abbreviations are the same as in figure 1.