Kinetic parameters of PAH-transport in control OK cells and in OK cells incubated with 10−6 mol/liter OTA for 72 hr
| Control | 72 Hr 10−6 mol/Liter OTA | |
|---|---|---|
| Basolateral uptake | ||
| Vmax [pmol · cm−2 · 30 min−1] | 578 ± 20 | 508 ± 13 |
| K m[μM] | 248 ± 21 | 508 ± 35 |
| Transepithelial secretion | ||
| Vmax [pmol · cm−2 · 30 min−1] | 490 ± 82 | 103 ± 21 |
| K m [μM] | 36 ± 17 | 22 ± 13 |
| Specific basolateral binding | ||
| Bmax [pmol · cm−2 · 60 min−1] | 20 ± 1 | 25 ± 4 |
| K m [μM] | 422 ± 13 | 924 ± 31 |
Values were determined as described in “Materials and Methods.”