Binding affinities (Ki values) of dopaminergic ligands at key receptors
| Ki (nM) | Ratios | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| hD3 | hD4 | h5-HT1A | hM1 | rat α1 | D4/D3 | 5-HT1A/D3 | M1/D3 | α1/D3 | |
| (+)-S 14297 | 4.9 | 13802-a | 748 | 1452-a | >100002-a | 282 | 153 | 30 | >2041 |
| GR 103,691 | 0.4 | 81 | 4.5 | >1000 | 12.6 | 203 | 11 | >2500 | 32 |
| Nafadotride | 0.5 | 269 | 46 | >10000 | 589 | 538 | 92 | >20000 | 1178 |
| (+)-UH 232 | 3.3 | 144 | 86 | >10000 | 661 | 44 | 26 | >3030 | 200 |
| (+)-AJ 76 | 26 | 214 | 305 | >10000 | 4169 | 8 | 12 | >385 | 160 |
| U 99194 | 160 | >10000 | 4230 | 2090 | 8913 | >62 | 26 | 13 | 56 |
Ki values at D3 receptors are those obtained with [3H]-(+)-PD 128,907. Values are the means of 2 to 3 determinations, each performed in triplicate.
↵2-a Millan et al., 1995.