Table 2

Catalytic activity of recombinant CYP2C19 proteins purified from bacteria

S-Mephenytoin hydroxylaseTolbutamide hydroxylase
nmol/min/nmol P450
2C19*1B23.0 ± 0.23.03 ± 0.05
2C19*6ND2-a ND2-b

CYP2C19*6 differs from wild-type CYP2C19*1B by a Arg132Gln change in exon 3.

  • 2-a ND = <0.06 nmol/nmol/min.

  • 2-b ND = 0.02 nmol/min/nmol/min.