Influence of S 18126, compared with L 745,870, raclopride and other benzamides, on several dopaminergic parameters
| 7-OH-DPAT Hypothermia | Apomorphine Climbing | Conditioned Avoidance | Catalepsy Induction | hD2 | hD3 | hD4 | |
|---|---|---|---|---|---|---|---|
| ID50 | ID50 | ID50 | AD50 | pKi | pKi | pKi | |
| S 18126 | 4.4 | 4.5 | >40 | >80 | 6.13 | 5.55 | 8.62 |
| L 745,870 | >10 | 15.8 | >2.5 | >10 | 6.05 | 5.40 | 8.60 |
| Raclopride | 0.033 | 0.015 | 0.071 | 0.2 | 8.97 | 8.87 | 5.29 |
| Bromopride | 1.4 | 1.3 | 1.4 | 5.7 | 7.84 | 7.89 | 6.15 |
| Eticlopride | 0.006 | 0.016 | 0.04 | 0.07 | 10.15 | 9.76 | 7.23 |
| Tiapride | 13.3 | 3.3 | >40 | >10 | 6.83 | 6.94 | 5.68 |
| Tropapride | 0.001 | 0.002 | 0.008 | 0.015 | 9.92 | 9.26 | 8.34 |
Doses are in mg/kg s.c.