Actions of drugs in models predictive of antipsychotic activity
| Amphetamine Locomotion | Cocaine Locomotion | Dizocilpine Locomotion | PCP Locomotion | Apomorphine Climbing | Conditioned Avoidance | DOI Head-Twitches | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | ID50 (95% CL) | % MOI (dose) | |
| S 18126 | 8.8 | 100 | 20.2 | 71 | >40.0 | 45 | >40 | 0 | 4.5 | 100 | >40 | 20 | 12.0 | 97 |
| (3.3–23.4) | (80.0) | (11.0–37.0) | (40.0) | (20.0) | (40.0) | N.C. | (10.0) | (40.0) | (6.9–20.8) | (40.0) | ||||
| L 745,870 | 6.3 | 60 | >10 | 42 | >10 | 0 | >10.0 | 40 | 15.8 | 83 | >2.5 | 2 | >10 | 37.5 |
| (3.2–12.4) | (10.0) | (10.0) | (10.0) | (5.0) | (9.2–27.2) | (40.0) | (2.5) | (2.5) | ||||||
| Raclopride | 0.15 | 100 | 0.07 | 100 | 0.05 | 88 | 0.3 | 100 | 0.015 | 100 | 0.07 | 98 | 0.04 | 100 |
| (0.11–0.20) | (0.63) | (0.04–0.13) | (0.63) | (0.02–0.17) | (0.63) | (0.1–0.5) | (10.0) | (0.009–0.03) | (0.16) | (0.03–0.17) | (0.63) | (0.03–0.07) | (0.16) | |
% MOI = % maximal observed inhibition. Doses are in mg/kg s.c. N.C. = not reliably computable.