Binding Site | Tissue | Radioligand (nM) | Nonspecific (μM) | Reference Ligand (Ki, nM) | S 16924 (Ki, nM) | Clozapine (Ki, nM) | Haloperidol (Ki, nM) |
---|---|---|---|---|---|---|---|
Rat D1 | Striatum | [3H]SCH 23390 (0.2) | (+)Butaclamol (3) | SCH 23390 (0.3) | 189.0 ± 20.0 | 186.4 ± 6.2 | 47.8 ± 8.0 |
Human D1 | L cells | [3H]SCH 23390 (1.0) | SCH 23390 (10) | SCH 23390 (0.5) | 43.4 ± 0.4 | 90.0 ± 4.5 | 25.1 ± 5.3 |
Rat D2 | Striatum | [3H]spiperone (0.2) | Raclopride (10) | Haloperidol (1.9) | 61.8 ± 9.8 | 218.5 ± 2.4 | 1.6 ± 0.1 |
Rat D2 | Striatum | [3H]raclopride (2.0) | Spiperone (10) | Haloperidol (1.0) | 24.4 ± 7.3 | 231.0 ± 40.0 | 1.0 ± 0.1 |
Cloned rat D2 | CHO cells | [3H]iodosulpride (2.0) | Raclopride (10) | 5-HT (4.6) | 57.3 ± 12.2 | 117.0 ± 37.0 | 0.9 ± 0.1 |
Human D2 | CHO cells | [3H]iodosulpride (0.1) | Raclopride (10) | Spiperone (0.06) | 46.3 ± 10.3 | 63.6 ± 1.5 | 0.4 ± 0.1 |
Cloned rat D3 | CHO cells | [3H]iodosulpride (2.0) | Spiperone (10) | Spiperone (2.0) | 56.5 ± 6.0 | 226.0 ± 27.0 | 3.7 ± 0.5 |
Human D3 | CHO cells | [3H]iodosulpride (0.2) | Raclopride (10) | 7-OH-DPAT (4.7) | 61.3 ± 10.7 | 298.0 ± 22.0 | 2.0 ± 0.3 |
Human D4 | CHO cells | [3H]spiperone (2.0) | Haloperidol (1.0) | Spiperone (1.6) | 9.4 ± 2.3 | 32.6 ± 0.7 | 1.9 ± 0.2 |
Human D5 | GH4 cells | [3H]SCH 23390 (0.3) | SCH 23390 (10) | SCH 23390 (0.4) | 34.0 ± 3.2 | 59.0 ± 4.7 | 28.0 ± 3.8 |
Rat DA reuptake | Rat striatum | [3H]BTCP (0.5) | BTCP (10) | Nomifensine (43.3) | >10000 | n.d. | n.d. |
All affinities are the means ± S.E.M. of ≥3 determinations. n.d., Not determined.