Effects of the schedule for administration of bismuth nitrate (BN) on the lethality of γ-irradiation in mice
| Treatment with BN | 137Cs Irradiation (Grays/Mouse) | Survival Rate (%) | |
|---|---|---|---|
| Dose (μmol/kg/day) | Timing | ||
| 0 | 0 | 100 | |
| 0 | 8 | 0 | |
| 100 × 2 | Days −3 and −2 | 8 | 43 |
| 100 × 2 | Days −2 and −1 | 8 | 71 |
| 100 × 2 | Days 0 and 1 | 8 | 0 |
| 100 × 2 | Days 1 and 2 | 8 | 0 |
| 100 × 2 | Days 2 and 3 | 8 | 0 |
Mice (n = 7) were pretreated s.c. with BN (100 μmol/kg) once a day for 2 days as indicated. Mice were irradiated on day 0, and the survival rate was determined 30 days after the irradiation.