AUC values after single-dose administration of M6G and morphine by either the i.v. or i.p. routes and M6G by the i.c.v. route to SD rats determined using both the tail flick (T.F.) and hotplate (H.P.) latency tests of antinociception
| Dosing route | Test | M6G dose | Morphine | Dose | ||
|---|---|---|---|---|---|---|
| 1.9 μmol | 3.8 μmol | 5.4 μmol | 10 μmol | 20 μmol | ||
| i.p. | H.P. | 5.6 ± 2 | 5.0 ± 2 | 5.5 ± 2.5 | 94.6 ± 41.8 | |
| i.p. | T.F. | 129 ± 23.4 | 265 ± 13 | 210.5 ± 19 | 247 ± 19 | |
| i.v. | H.P. | 14.2 ± 7 | 14.1 ± 11 | 111 ± 21 | ||
| i.v. | T.F. | 267.0 ± 20.7 | 268 ± 10 | 255 ± 5.5 | ||
| M6G dose | ||||||
| 0.22 nmol | 1.25 nmol | 2.2 nmol | 3.3 nmol | |||
| i.c.v. | H.P. | 2.3 ± 1.2 | 28.7 ± 11.8 | 72.3 ± 22 | 96.2 ± 29 | |
| i.c.v. | T.F. | 26.7 ± 10.8 | 193.4 ± 37.5 | 221.1 ± 24.9 | 245.5 ± 25.8 | |
Units for the AUC values are %MPE.hr.
Values are mean ± S.E.M.