Histological evaluation of gastric ulcer healing after repeated administration of NS-398 and indomethacin to rats
| Length of Regenerated Mucosa (mm) | Thickness of Ulcer Base (mm) | Number of Microvessels (counts/mm2) | |
|---|---|---|---|
| Control | 2.20 ± 0.25 | 1.08 ± 0.12 | 50.2 ± 2.6 |
| NS-398 (6 mg/kg) | 1.42 ± 0.13* | 1.53 ± 0.10* | 26.1 ± 3.7* |
| Indomethacin (2 mg/kg) | 0.98 ± 0.06*# | 1.62 ± 0.15* | 17.5 ± 1.9*# |
The vehicle (control), 6 mg/kg NS-398 or 2 mg/kg indomethacin was repeatedly administered starting from day 0, and then the length of the regenerated mucosa, thickness of the ulcer base and microvessel density in the base were histologically determined on day 14.