Table 5
Binding kinetics of XV459 to human platelets as compared with that of c7E3
Binding Parameters
XV459
c7E3
K
d
(μM)
Unactivated
0.0025 ± 0.00098
0.0091 ± 0.0005
Activated
0.0008 ± 0.0002
0.0092 ± 0.0006
Dissociation rates
(t½, minutes)
7.0
40.0