Table 4

Kd (μM) determinations of XV459 binding to platelets obtained from various animal species

nMeanKd (μM) ± S.E.M.
UnactivatedActivated
Human60.0025  ± 0.00100.0008  ± 0.0002
Canine30.0024  ± 0.00140.0028  ± 0.001
Baboon10.00380.0049
Swine30.1210  ± 0.02750.1223  ± 0.0257
  • Data represent mean ± S.E.M., n = 3 to 6, except for baboon, which was based on pooled platelets from three different animals.