Table 2

Comparative antiplatelet efficacy of XV459 vs. c7E3 in inhibiting human platelet aggregation induced by various agonists

Test AgentIC50 (μM) ± S.E.M.
ADP (100 μM)TEAC2-150Thrombin2-160
XV4590.030  ± 0.00650.022  ± 0.0030.022  ± 0.006
c7E30.054  ± 0.00190.071  ± 0.0070.064  ± 0.016

Platelet aggregation (light transmittance aggregometry) was induced by adding the various agonists to PRP obtained from human blood in citrate tubes.

  • ↵2-150  TEAC: thrombin (0.001 I.U./ml), epinephrine (100 μM), ADP (100 μM) and collagen (20 μg/ml).

  • ↵2-160  Thrombin at 0.5 IU/ml. Data represent mean ± S.E.M.,n = 3 for each individual agonist.