Antiplatelet efficacy of XV459 in inhibiting human platelet aggregation induced by various agonists in citrate vs. heparin
| AGONISTS | IC50 (μM) — vs.XV459 | |
|---|---|---|
| Citrate | Heparin | |
| ADP (100 μM) | 0.030 ± 0.0065 | 0.031 ± 0.0035 |
| TRAP (10 μM) | 0.053 ± 0.0052 | 0.063 ± 0.0049 |
| Collagen (20 μg/ml) | 0.031 ± 0.0025 | 0.047 ± 0.0062 |
Platelet aggregation (light transmittance aggregometry) was induced by adding the various agonists to PRP obtained from human blood in either citrate or heparin tubes. Data represent mean ± S.E.M.,n = 3 to 5 for each individual agonist.