Table 2

Influence of S 16924 as compared to clozapine and haloperidol in various tests of antipsychotic properties involving serotonergic and/or dopaminergic activity

	Hyperlocomotion		Head-Twitches		Drug discrimination: lever selection		Drug discrimination: response rate
	PCP		DOI		DS = DOI		DS = Clozapine		DS = S 16924		DS = DOI		DS = Clozapine		DS = S 16924
Drug	ID₅₀	% MOE	ID₅₀	% MOE	ED₅₀	% MOA	ED₅₀	% MOG	ED₅₀	% MOG	ID₅₀	% MOI	ID₅₀	% MOI	ID₅₀	% MOI
	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)
S 16924	0.02	100	0.15	100	0.17	100	0.7	100	0.02^a	100	>0.63	0	1.7	62	>0.16^a	0
	(0.01–0.03)	(0.16)	(0.11–0.2)	(0.63)	(0.12–0.2)	(0.63)	(0.4–1.1)	(2.5)	(0.01–0.03)	(0.16#)		(0.63)	(0.8–3.4)	(2.5)		(0.16#)
Clozapine	0.07	100	0.04	100	0.05	86	1.7^a	100	0.2	83	>0.16	0	8.7^a	60	>1.25	11
	(0.04–0.01)	(0.63)	(0.01–0.11)	(2.5)	(0.02–0.11)	(0.16)	(0.1–5.2)	(6.3)	(0.1–1.1)	(1.25)		(0.16)	(2.7–28.5)	(6.3#)		(0.63)
Haloperidol	0.08	100	0.07	100	>0.16	20	>0.06	33	∼0.08	50	0.06	90	0.02	91	0.04	81
	(0.06–0.12)	(0.63)	(0.04–0.11)	(0.63)		(0.01)		(0.04)		(0.08)	(0.03–0.13)	(0.16)	(0.01–0.04)	(0.06)	(0.02–0.08)	(0.08)

DS, Discriminative stimulus; ID₅₀, inhibitory dose₅₀; ED₅₀, effective dose₅₀; CL, confidence limit; % MOE, % maximal observed effect; % MOA, % maximal observed antagonism; % MOG, % maximal observed generalization and % MOI, % maximal observed inhibition.
Doses are in mg/kg, s.c. or i.p. (a).