Table 1

Influence of S 16924 as compared to clozapine and haloperidol in various procedures predictive of antipsychotic (antiproductive) properties

	Rotation		Hyperlocomotion		Climbing		Cond. Avoid.
	Quinpirole		SKF 38393		Amphetamine		Cocaine		Dizocilpine		Apomorphine		Responses
Drug	ID₅₀	% MOE	ID₅₀	% MOE	ID₅₀	% MOE	ID₅₀	% MOE	ID₅₀	% MOE	ID₅₀	% MOE	ID₅₀	% MOE
	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose)	(95% CL)	(Dose	(95% CL)	(Dose)	(95% CL)	(Dose)
S 16924	0.8	92	1.7	97	2.4	100	0.9	100	1.1	100	0.17	100	1.4	96
	(0.3–1.9)	(2.5)	(0.8–3.5)	(10.0)	(1.6–3.7)	(10.0)	(0.4–1.7)	(10.0)	(0.8–1.4)	(2.5)	(0.08–0.4)	(2.5)	(0.8–2.3)	(10.0)
Clozapine	0.6	93	2.0	81	8.6	100	1.9	(100)	1.5	96	1.9	100	4.9	71
	(0.2–1.4)	(2.5)	(0.5–7.3)	(10.0)	(6.2–11.8)	(40.0)	(0.7–4.8)	(40.0)	(0.6–3.6)	(10.0)	(1.5–2.4)	(5.0)	(2.9–8.4)	(10.0)
Haloperidol	0.02	100	1.8	59	0.04	100	0.02	100	0.10	99	0.01	100	0.08	97
	(0.01–0.04)	(0.63)	(0.5–6.8)	(2.5)	(0.03–0.06)	(0.16)	(0.01–0.04)	(0.16)	(0.07–0.14)	0.63	(0.01–0.02)	(0.16)	(0.04–0.16)	(0.63)

All values are ID₅₀s (95% CL) = inhibitory dose₅₀s (95% confidence limits), together with % maximal observed effects (MOE) (dose at which obtained). Doses are in mg/kg, s.c.