Effects of NMDA receptor antagonists on the weight changes produced by saline (instead of naloxone) injection in morphine-dependent rats
| Dizocilpine | Dose (mg/kg) | Vehicle | 0.1 |
| Weight loss | 0.2 ± 0.4 | −1.8 ± 0.41-a | |
| n | 8 | 8 | |
| d-CPPene | Dose (mg/kg) | Vehicle | 10 |
| Weight loss | 0.9 ± 0.3 | −5.5 ± 1.01-a | |
| n | 8 | 8 | |
| Memantine | Dose (mg/kg) | Vehicle | 30 |
| Weight loss | 0.1 ± 0.2 | −2.1 ± 0.51-a | |
| n | 8 | 8 | |
| Eliprodil | Dose (mg/kg) | Vehicle | 30 |
| Weight loss | 1.2 ± 0.6 | 0.0 ± 0.3 | |
| n | 8 | 8 | |
| ACEA-1021 | Dose (mg/kg) | Vehicle | 50 |
| Weight loss | 0.7 ± 0.3 | 0.2 ± 0.5 | |
| n | 7 | 7 |
Mean (±S.E.M.) body weight change (% from baseline) after the administration of saline (s.c.) with i.p. NMDA receptor antagonists.
↵1-a P < .05 (Wilcoxon’s test), compared with Vehicle tests.