Table 1

Pharmacodynamic estimates obtained by population analysis of concentration-effect data after l-propranolol anddl-metoprolol administration to SHR (mean ± S.E.)

E0 (beats · min−1)Imax (beats · min−1)IC50 (ng · ml−1)m (beats · ml · (min · μg)−1)fu (%)
l-Propranololn 1-a = 22
 Total388  ± 4−83  ± 618.1  ± 4.328.9  ± 2.85.3  ± 0.51-b
 Unbound388  ± 4−89  ± 71.14  ± 0.27343  ± 51
dl-Metoprololn 1-a = 19
 Total396  ± 6−103  ± 650.6  ± 15.24.48  ± 0.39881-c

  • ↵1-a All animals.

  • ↵1-b Free fraction at the linear relationship.

  • ↵1-c Data taken from Brogden et al., 1977.