The pharmacokinetics and pharmacodynamics of various insulin analogues in chronic diabetic minipigs in comparison with human insulin
| Insulin | AspB9GluB27 | AspB9 | GluB27 | AspB28 | |
|---|---|---|---|---|---|
| Pharmacokinetics | |||||
| ΔCmaxdata | 100 | 262 | 232 | 77 | 143 |
| ΔAUC0→6 data | 100 | 277 | 280 | 72 | 74 |
| MRT data | 100 | 87 | 103 | 96 | 82 |
| Pharmacodynamics | |||||
| Δnadir data | 100 | 93 | 103 | 90 | 79 |
| ABGC0→12data | 100 | 79 | 102 | 92 | 68 |