Competition binding parameters in murine cerebellum
| n | Hill slope | −logKi high | −log Ki low | % High-affinity sites | |
|---|---|---|---|---|---|
| Methoxamine | 6 /3 | 0.73 ± 0.08 | — | 4.50 ± 0.18 | — |
| (+)-Niguldipine | 5 /1 | 0.80 ± 0.05 | — | 7.81 ± 0.09 | — |
| Noradrenaline | 4 /1 | 0.88 ± 0.09 | — | 5.34 ± 0.12 | — |
| SB 216469 | 5 /2 | 0.62 ± 0.04 | — | 7.85 ± 0.32 | — |
| Tamsulosin | 6 /6 | 0.51 ± 0.07 | 11.05 ± 0.31 | 9.10 ± 0.21 | 56 ± 4 |
Data are means ± S.E.M. of n experiments, where the first number indicates the number of experiments that were performed and the second number indicates the number of competition curves that were significantly better explained by a two-site model. The Hill slope refers to a monophasic fit. Affinity estimates for biphasic fits are based on fitting to a two-site model in which a Hill slope of unity was assumed for each component; these data are given only for compounds where more than half of all curves were biphasic.