Parameter | SD − 1° response | SD − 2° response | MD − 1° response | ||
---|---|---|---|---|---|
Dose model equation (6) | Sigmoid function equation (5) | Ch5c8 | Hu5c8 | ||
CMAX,ATT(titer)2-b | 1880 | 1885 | 2727 | 1811 | 1776 |
TMAX,ATT (h)2-b | 432 | 432 | 240 | 624 | 624 |
TT0 | 3867 | 4168 | 8430 | 5897 | 6885 |
(714) | (341) | (1826) | (1052) | (1653) | |
k ab(control) (/h) × 103 | 6.99 | 6.48 | 5.30 | 2.92 | 2.30 |
(2.25) | (0.122) | (0.597) | (0.601) | ||
k b (/h) × 103 | 1.92 | 2.52 | 5.17 | 1.87 | 1.99 |
(0.658) | (0.469) | (0.124) | (0.537) | (0.584) | |
k d (/h) × 103 | 2.35 | 2.31 | 2.31 | 2.31 | 2.31 |
(0.540) | |||||
Tlag (h) | 240 | 240 | 96 | 360 | 351 |
(11.33) | (13.08) | ||||
IC50(μg/ml) | 1762-c | 0.845 | 0.845 | 0.845 | 0.845 |
(56.5) | (0.267) | ||||
Imax | 0.85 | 0.837 | 0.837 | 0.837 | 0.837 |
(0.03) | (0.021) |