Table 4

Pharmaco-EEG evaluation in free-moving rats (the results are shown as percentage of base-line duration)

Compound  Dose (mg/kg)   and Route (N)Quiet WakingREM Sleep
Fluoxetine1 i.p.  (8)2−45
2.2 i.p.  (8)−176
3.2 i.p.  (6)−8−37
4.6 i.p.  (9)−4−51
10 i.p.  (8)55−100*
32 i.p.  (7)126*−81*
Ro 60-0175 (ORG 35030)2.2 i.p.  (7)94*−81
3.2 p.o.  (8)6−61
10 p.o.  (8)63−100*
22 p.o.  (7)96*−100*
Ro 60-0332 (ORG 35035)1 i.p.  (8)19−8
3.2 i.p.  (7)84*−47*
10 i.p.  (7)370*−100*
3.2 p.o.  (7)30−64
10 p.o.  (8)7643
32 p.o.  (5)122*−65*
  • Note: * P < .05 for comparison with vehicle control.